Assessment of Risk Factors for Dental Developmental Disorders in Pediatric Cancer Survivors
이지현, 최형준, 이제호, 송제선, 강정민,
소속 상세정보
이지현 ( Lee Ji-Hyun ) -
최형준 ( Choi Hyung-Jun ) - Yonsei University College of Dentistry Department of Pediatric Dentistry
이제호 ( Lee Jae-Ho ) - Yonsei University College of Dentistry Department of Pediatric Dentistry
송제선 ( Song Je-Seon ) - Yonsei University College of Dentistry Department of Pediatric Dentistry
강정민 ( Kang Chung-Min ) - Yonsei University College of Dentistry Department of Pediatric Dentistry
Abstract
This study was to examine the developmental dental abnormalities in childhood cancer survivors. Risk factors were assessed for 125 children with radiographic data through a retrospective analysis of medical records and panoramic images. 68.0% of childhood cancer survivors exhibited at least one dental abnormality. The types of abnormalities varied depending on the age at cancer diagnosis and treatment intensity, ranging from microdontia (43.2%), to abnormal root development (39.2%) and tooth agenesis (33.6%). Logistic regression analysis demonstrated that a young age at diagnosis (under 3 years), the use of heavy metal agents, a history of hematopoietic stem cell transplantation (HSCT), and combination treatment of chemotherapy, radiation therapy, and HSCT were associated with a significantly higher risk for overall dental abnormalities. The increased risk ratios were 6.00, 3.06, 3.22, and 7.87, respectively (p < 0.05). The results of this study will predict dental abnormality in permanent dentition according to the diagnosis age and treatment method of childhood cancer.
키워드
Childhood cancer; Dental abnormality; Tooth agenesis; Microdontia; Abnormal root development
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